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Ausgewählte Publikationen des NRZ für Influenza

Kissling E, Valenciano M, Pozo F, Vilcu AM, Reuß A, Rizzo C, Larrauri A, Horváth JK, Brytting M, Domegan L, Korczyńska M, Meijer A, Machado A, Ivanciuc A, Višekruna Vučina V, van der Werf S, Schweiger B et al.; I-MOVE/I-MOVE+ study team (2017): 2015/16 I-MOVE/I-MOVE+ multicentre case control study in Europe: moderate vaccine effectiveness estimates against influenza A(H1N1)pdm09 and low estimates against lineage mismatched influenza B among children.
Influenza Other Respir. Viruses: Epub Nov 10. doi: 10.1111/irv.12520.
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Duwe S (2017): Influenza viruses – antiviral therapy and resistance.
GMS Infect. Dis. 5: Doc04. Epub Apr 25. doi: 10.3205/id000030.
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Rath B, Conrad T, Myles P, Alchikh M, Ma X, Hoppe C, Tief F, Chen X, Obermeier P, Kisler B, Schweiger B (2017): Influenza and other respiratory viruses: standardizing disease severity in surveillance and clinical trials.
Expert Rev. Anti Infect. Ther. 15 (6): 545–568. Epub May 12. doi: 10.1080/14787210.2017.1295847.
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Rath B, Chen X, Spies V, Muehlhans S, Obermeier P, Tief F, Seeber L, Karsch K, Milde J, Skopnik H, Schweiger B, Duwe S (2017): Prospective surveillance of antiviral resistance in hospitalized infants less than 12 months of age with A(H3N2) influenza infection and treated with oseltamivir.
Antivir. Ther. 22: 515-522. Epub Feb 16. doi: 10.3851/IMP3141.
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Venkatesan S, Myles PR, Leonardi-Bee J, Muthuri SG, Al Masri M, Andrews N, Bantar C, Dubnov-Raz G, Gérardin P, Koay ES, Loh TP, Memish Z, Miller E, Oliva ME, Rath BA, Schweiger B et al. (2017): Impact of outpatient neuraminidase inhibitor treatment in patients infected with influenza A(H1N1)pdm09 at high risk of hospitalization: an Individual Participant Data (IPD) meta-analysis.
Clin. Infect. Dis. 64 (10): 1328-1334. Epub Feb 12. doi: 10.1093/cid/cix127.
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Seeber L, Conrad T, Hoppe C, Obermeier P, Chen X, Karsch K, Muehlhans S, Tief F, Böttcher S, Diedrich S, Schweiger B, Rath B (2017): Educating parents about the vaccination status of their children: A user-centered mobile application.
Prev. Med. Rep. 5: 241–250. Epub Jan 14. doi: 10.1016/j.pmedr.2017.01.002.
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Broberg E, Hungnes O, Schweiger B et al. (2016): Improving influenza virological surveillance in Europe: strain-based reporting of antigenic and genetic characterisation data, 11 European countries, influenza season 2013/14.
Euro Surveill. 21 (41): pii=30370. Epub Oct 13. doi: 10.2807/1560-7917.ES.2016.21.41.30370.
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Hanitsch LG, Löbel M, Mieves JF, Bauer S, Babel N, Schweiger B et al. (2016): Cellular and humoral influenza-specific immune response upon vaccination in patients with common variable immunodeficiency and unclassified antibody deficiency.
Vaccine 34 (21): 2417–2423. Epub Apr 4. doi: 10.1016/j.vaccine.2016.03.091.
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Karsch K, Chen X, Miera O, Peters B, Obermeier P, Francis RC, Amann V, Duwe S, Fraaij P, Heider A, de Zwart M, Berger F, Osterhaus AD, Schweiger B, Rath B (2016): Pharmacokinetics of oral and intravenous Oseltamivir treatment of severe influenza B virus infection requiring organ replacement therapy.
Eur. J. Drug Metab. Pharmacokinet.: Epub Mar 19. doi: 10.1007/s13318-016-0330-9.
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Jürchott K, Schulz AR, Bozzetti C, Pohlmann D, Stervbo U, Warth S, Mälzer JN, Waldner J, Schweiger B et al. (2016): Highly predictive model for a protective immune response to the A(H1N1)pdm2009 influenza strain after seasonal vaccination.
PLoS One 11 (3): e0150812. Epub Mar 8. doi: 10.1371/journal.pone.0150812.
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Tief F, Hoppe C, Seeber L, Obermeier P, Chen X, Karsch K, Mühlhans S, Adamou E, Conrad T, Beresniak A, Schweiger B et al. (2016): An inception cohort study assessing the role of pneumococcal and other bacterial pathogens in children with influenza and ILI and a clinical decision model for stringent antibiotic use.
Antivir. Ther. 21: 413-424. Epub Feb 11. doi: 10.3851/IMP3034.
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Lehners N, Tabatabai J, Prifert C, Wedde M, Puthenparambil J, Weissbrich B, Biere B, Schweiger B et al. (2016): Long-term shedding of influenza virus, parainfluenza virus, respiratory syncytial virus and nosocomial epidemiology in patients with hematological disorders.
PLoS One 11 (2): e0148258. Epub Feb 11. doi: 10.1371/journal.pone.0148258.
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Muthuri SG, Venkatesan S, Myles PR et al., PRIDE Consortium Investigators (for RKI Schweiger B), Nguyen-Van-Tam JS (2016): Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.
Influenza Other Respir. Viruses 10 (3): 192–204. Epub Feb 1. doi: 10.1111/irv.12363.
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Valenciano M, Kissling E, Reuß A et al.; on behalf of the I-MOVE multicentre case–control team (for Germany Buda S, Prahm K, Schweiger B, Wedde M, Biere B) (2016): Vaccine effectiveness in preventing laboratory-confirmed influenza in primary care patients in a season of co-circulation of influenza A(H1N1)pdm09, B and drifted A(H3N2), I-MOVE Multicentre Case–Control Study, Europe 2014/15.
Euro Surveill. 21 (7): pii=30139.
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Wedde M, Biere B, Wolff T, Schweiger B (2015): Evolution of the hemagglutinin expressed by human influenza A(H1N1)pdm09 and A(H3N2) viruses circulating between 2008-2009 and 2013-2014 in Germany.
Int. J. Med. Microbiol. 305 (7): 762-775. Epub Aug 21. doi: 10.1016/j.ijmm.2015.08.030.
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Blümel B, Schweiger B, Dehnert M, Buda S, Reuß A, Czogiel I, Kamtsiuris P, Schlaud M, Poethko-Müller C, Thamm M, Haas W (2015): Age-related prevalence of cross-reactive antibodies against influenza A(H3N2) variant virus, Germany, 2003 to 2010.
Euro Surveill. 20 (32): pii=21206. Epub Aug 13.
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Ampofo WK, Azziz-Baumgartner E et al.; WHO Writing Group (for RKISchweiger B) (2015): Strengthening the influenza vaccine virus selection and development process: Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1–3 April 2014.
Vaccine 33 (36): 4368–4382. doi: 10.1016/j.vaccine.2015.06.090.
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Brückner S, Agnandji ST, Berberich S, Bache E, Fernandes JF, Schweiger B et al. (2015): Effect of antihelminthic treatment on vaccine immunogenicity to a seasonal influenza Vaccine in primary school children in Gabon: a randomized placebo-controlled trial.
PLoS Negl. Trop. Dis. 9 (6): e0003768. Epub Jun 8. doi: 10.1371/journal.pntd.0003768.
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Valenciano M, Kissling E, Reuß A et al.; I-MOVE Multicentre Case Control Study Team (for RKI Buchholz U, Buda S, Prahm K, Schweiger B, Wedde M) (2015): The European I-MOVE Multicentre 2013–2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2).
Vaccine 33 (24): 2813–2822. Epub Apr 28. doi: 10.1016/j.vaccine.2015.04.012.
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Reiche J, Böttcher S, Diedrich S, Buchholz U, Buda S, Haas W, Schweiger B, Wolff T (2015): Low-level circulation of enterovirus D68-associated acute respiratory infections, Germany, 2014.
Emerg. Infect. Dis. 21 (05): 837–841. doi: 10.3201/eid2105.141900.
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Hahn M, Schnitzler P, Schweiger B et al. (2015): Efficacy of single versus boost vaccination against influenza virus in patients with multiple myeloma.
Haematologica 100 (7): e285-288. Epub Mar 27. doi: 10.3324/haematol.2014.116772.
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Heider A, Mochalova L, Harder T, Tuzikov A, Bovin N, Wolff T, Matrosovich M, Schweiger B (2015): Alterations in hemagglutinin receptor-binding specificity accompany the emergence of highly pathogenic avian influenza viruses.
J. Virol. 89 (10): 5395-5405. Epub Mar 4. doi: 10.1128/JVI.03304-14.
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Broberg E, Snacken R, Adlhoch C et al.; on behalf of the WHO European Region and the European Influenza Surveillance Network (for GermanyBuda S, Schweiger B) (2015): Start of the 2014/15 influenza season in Europe: drifted influenza A(H3N2) viruses circulate as dominant subtype.
Euro Surveill. 20 (4): pii=21023.
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Tuttle R, Weick A, Schwarz WS, Chen X, Obermeier P, Seeber L, Tief F, Muehlhans S, Karsch K, Peiser C, Duwe S, Schweiger B, Rath B (2015): Evaluation of novel second-generation RSV and influenza rapid tests at the point of care.
Diagn. Microbiol. Infect. Dis. 81 (3): 171-176. Epub 2014 Dec 3. doi: 10.1016/j.diagmicrobio.2014.11.013.
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Rakers C, Schwerdtfeger SM, Mortier J, Duwe S, Wolff T et al. (2014): Inhibitory potency of flavonoid derivatives on influenza virus neuraminidase.
Bioorg. Med. Chem. Lett. 24 (17): 4312–4317. Epub Jul 18. doi: 10.1016/j.bmcl.2014.07.010.
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Muthuri SG, Venkatesan S, Myles PR et al. (for RKI Schweiger B) (2014): Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data.
Lancet Respir. Med. 2 (5): 395–404. Epub Mar 19. doi: 10.1016/S2213-2600(14)70041-4.
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Chen X, Pouran Yousef K, Duwe S, Karsch K, Grover S, Wählisch S, Obermeier P, Tief F, Mühlhans S, Seeber L, von Kleist M, Schweiger B, Rath B (2014): Quantitative influenza follow-up testing (QIFT) - A novel biomarker for the monitoring of disease activity at the point-of-care.
PLoS One 9 (3): e92500. Epub Mar 21. doi: 10.1371/journal.pone.0092500.
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Embarek Mohamed MS, Reiche J, Jacobsen S, Thabit AG, Badary MS, Brune W, Schweiger B et al. (2014): Molecular Analysis of Human Metapneumovirus Detected in Patients with Lower Respiratory Tract Infection in Upper Egypt.
Int. J. Microbiol. 2014: Article ID 290793. Epub Jan 30. doi: 10.1155/2014/290793.
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Reiche J, Jacobsen S, Neubauer K, Hafemann S, Nitsche A, Milde J, Wolff T, Schweiger B (2014): Human metapneumovirus: insights from a ten-year molecular and epidemiological analysis in Germany.
PLoS One 9 (2): e88342. Epub Feb 5. doi: 10.1371/journal.pone.0088342.
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Schweiger B, Buda S (2013): Erkennung von Influenzaausbrüchen und Rolle der virologischen Diagnostik.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56 (1): 28-37. Epub 2012 Dec 19. doi: 10.1007/s00103-012-1580-6.
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Rath B, Tief F, Karsch K, Muehlhans S, Obermeier P, Adamou E, Chen X, Seeber L, Peiser C, Hoppe C, von Kleist M, Conrad T, Schweiger B (2013): Towards a personalised approach to managing of influenza infections in infants and children – Food for thought and a note on oseltamivir.
Infect. Disord. Drug Targets 13 (1): 25-33. Epub May 8. DOI: 10.2174/18715265112129990005.
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Wedde M, Wählisch S, Wolff T, Schweiger B (2013): Predominance of HA-222D/G polymorphism in influenza A(H1N1)pdm09 viruses associated with fatal and severe outcomes recently circulating in Germany.
PLoS ONE 8 (2): e57059. Epub Feb 25. doi: 10.1371/journal.pone.0057059.
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Buchholz U, Müller MA, Nitsche A, Sanewski A, Wevering N, Bauer-Balci T, Bonin F, Drosten C, Schweiger B, Wolff T, Muth D, Meyer B, Buda S, Krause G, Schaade L, Haas W (2013): Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October–November 2012.
Euro Surveill. 18 (8): pii: 20406.
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Rambal V, Müller K, Dang-Heine C, Sattler A, Dziubianau M, Weist B, Luu SH, Stoyanova A, Nickel P, Thiel A, Neumann A, Schweiger B et al. (2013): Differential influenza H1N1-specific humoral and cellular response kinetics in kidney transplant patients.
Med. Microbiol. Immunol.: Epub Sep 22. doi: 10.1007/s00430-013-0312-3.
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Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T (2013): The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue.
MBio 4 (5): e00601–13. Epub Oct. 8. doi: 10.1128/mBio.00601-13.
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Simonsen L, Spreeuwenberg P, Lustig R et al.; the GLaMOR Collaborating Teams (for Germany Buchholz U, Schweiger B, Höhle M) (2013): Global mortality estimates for the 2009 influenza pandemic from the GLaMOR project: a modeling study.
PLoS Med. 10 (11): e1001558. Epub Nov 26. doi: 10.1371/journal.pmed.1001558.
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Suess T, Remschmidt C, Schink S, Schweiger B, Heider A, Milde J, Nitsche A, Schroeder K, Doellinger J, Braun C, Haas W, Krause G, Buchholz U (2012): Comparison of Shedding Characteristics of Seasonal Influenza Virus (Sub)Types and Influenza A(H1N1)pdm09; Germany, 2007–2011.
PLoS One 7 (12): e51653. Epub Dec 11. doi: 10.1371/journal.pone.0051653.
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Corman VM, Müller MA, Costabel U, Timm J, Binger T, Meyer B, Kreher P, Lattwein E, Eschbach-Bludau M, Nitsche A, Bleicker T, Landt O, Schweiger B, Drexler JF, Osterhaus AD, Haagmans BL, Dittmer U, Bonin F, Wolff T, Drosten C (2012): Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections.
Euro Surveill. 17 (49): pii: 20334.
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Rath B, Tief F, Obermeier P, Tuerk E, Karsch K, Muehlhans S, Adamou E, Duwe S, Schweiger B (2012): Early detection of influenza A and B infection in infants and children using conventional and fluorescence-based rapid testing.
J. Clin. Virol. 55 (4): 329–333. Epub Aug 23. DOI 10.1016/j.jcv.2012.08.002.
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Remschmidt C, Stöcker P, an der Heiden M, Suess T, Luchtenberg M, Schink S, Schweiger B, Haas W, Buchholz U (2012): Preventable and non-preventable risk factors for influenza transmission and hygiene behavior in German influenza households, pandemic season (H1N1) 2009/2010.
Influenza Other Respi. Viruses: Epub Jul 16. doi: 10.1111/j.1750-2659.2012.00407.x.
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Hellenbrand W, Jorgensen P, Schweiger B, Falkenhorst G, Nachtnebel M, Greutélaers B, Traeder C, Wichmann O (2012): Prospective hospital-based case-control study to assess the effectiveness of pandemic influenza A(H1N1)pdm09 vaccination and risk factors for hospitalization in 2009–2010 using matched hospital and test-negative controls.
BMC Infect. Dis. 12: 127. doi: 10.1186/1471-2334-12-127.
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Frickmann H, Scherpe S, Schweiger B, Wählisch S et al. (2012): Despite triple vaccination..
J. Clin. Virol. 54 (4): 291-294. Epub May 12. doi: 10.1016/j.jcv.2012.04.011.

Rath B, von Kleist M, Tief F, Karsch K, Tuerk E, Muehlhans S, Louis F, Skopnik H, Schweiger B, Duwe S (2012): Virus load kinetics and resistance development during oseltamivir treatment in infants and children infected with influenza A (H1N1) 2009 and influenza B viruses.
Pediatr. Infect. Dis. J. 31 (9): 899-905. Epub May 10. doi: 10.1097/INF.0b013e31825c7304.
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Nachtnebel M, Greutelaers B, Falkenhorst G, Jorgensen P, Dehnert M, Schweiger B, Traeder C, Buda S, Eckmanns T, Wichmann O, Hellenbrand W (2012): Lessons from a one-year hospital-based surveillance of acute respiratory infections in Berlin – comparing case definitions to monitor influenza.
BMC Public Health 12 (1): 245. doi:10.1186/1471-2458-12-245.
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Martirosyan L, Paget WJ, Jorgensen P, Brown CS, Meerhoff TJ, Pereyaslov D, Mott JA, EuroFlu group (for Germany Schweiger B, Buda S) (2012): The community impact of the 2009 influenza pandemic in the WHO European region: a comparison with historical seasonal data from 28 countries.
BMC Infect. Dis. 12: 36. doi:10.1186/1471-2334-12-36.
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Suess T, Remschmidt C, Schink S, Schweiger B, Nitsche A, Schroeder K, Doellinger J, Milde J, Haas W, Koehler I, Krause G, Buchholz U (2012): The role of facemasks and hand hygiene in the prevention of influenza transmission in households: results from a cluster randomised trial; Berlin, Germany, 2009–2011.
BMC Infect. Dis. 12 (1): 26. Epub Jan 26. doi:10.1186/1471-2334-12-26.
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Roll D, Ammer J, Holler B, Salzberger B, Schweiger B et al. (2012): Vaccination against pandemic H1N1 (2009) in patients after allogeneic hematopoietic stem cell transplantation: a retrospective analysis.
Infection 40 (2): 153-161. Epub 2011 Oct 29. DOI: 10.1007/s15010-011-0206-5.
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Eggers M, Roth B, Schweiger B et al. (2012): Comparison of the novel ResPlex III assay and existing techniques for the detection and subtyping of influenza virus during the influenza season 2006–2007.
Eur. J. Clin. Microbiol. Infect. Dis. 31 (6): 1257-1265. Epub 2011 Oct 20. DOI: 10.1007/s10096-011-1437-1.
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WHO Writing Group, Ampofo WK et al. (for RKI Schweiger B) (2011): Improving influenza vaccine virus selection: report of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010.
Influenza Other Respir. Viruses: Epub Aug 8. doi: 10.1111/j.1750-2659.2011.00277.x.
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Shayegi N, Schweiger B, Duwe S et al. (2011): Antiviral treatment of Influenza A (H1N1-09) guided by molecular resistance testing in aplasia after allo-SCT.
Bone Marrow Transplant. 46 (11): 1492-1494. Epub Jan 17. doi:10.1038/bmt.2010.331.
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Duwe S, Wedde M, Birkner P, Schweiger B (2011): Genotypic and phenotypic resistance of pandemic A/H1N1 influenza viruses circulating in Germany.
Antiviral Res. 89 (1): 115–118. Epub 2010 Nov 9. doi:10.1016/j.antiviral.2010.11.001.
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Schulze M, Nitsche A, Schweiger B, Biere B (2010): Diagnostic approach for the differentiation of the pandemic influenza A(H1N1)v virus from recent human influenza viruses by real-time PCR.
PLoS One 5 (4): e9966.
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Biere B, Bauer B, Schweiger B (2010): Differentiation of influenza B virus lineages Yamagata and Victoria by real-time PCR.
J. Clin. Microbiol. 48 (4): 1425-1427. Epub Jan 27.
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Biere B, Schweiger B (2010): Human adenoviruses in respiratory infections: Sequencing of the hexon hypervariable region reveals high sequence variability.
J. Clin. Virol. 47 (4): 366-371. Epub Feb 9.
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Reiche J, Schweiger B (2009): Genetic variability of group A human respiratory syncytial virus strains circulating in Germany from 1998 to 2007.
J. Clin. Microbiol. 47 (6): 1800-1810. Epub Apr 22.
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Duwe S, Schweiger B (2008): A new and rapid genotypic assay for the detection of neuraminidase inhibitor resistant influenza A viruses of subtype H1N1, H3N2, and H5N1.
J. Virol. Methods 153 (2): 134-141.
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