The "Centre for Artificial Intelligence in Public Health Research" (ZKI-PH) is responsible for the strategic support of advances in the field of public health research using the latest AI-based technologies at the RKI. At ZKI-PH, the topics of bioinformatics, computational epidemiology, modern data visualisation as well as big data and systems analysis are combined with the central methodological building blocks of machine learning, AI, decision making research as well as the development of realistic computer simulations in the field of public health research. To meet these challenges, the ZKI-PH develops models and simulations for the corresponding subject areas, promotes the utilisation/transfer of existing solutions into public health applications and prepares the results and underlying data for the public and political stakeholders. The aim of this interdepartmental cooperation in the field of Artificial Intelligence (AI) is to gain a comprehensive understanding of the spread and prevention of diseases in the population and to counter epidemics of the 21st century even more effectively.