ZBS 3: Biological Toxins

Consultant laboratory for neurotoxin-producing clostridia (botulism, tetanus)

Date:  25/04/2025

Leader: 
Dr. Brigitte Dorner
Deputy: 
Dr. Martin Dorner

Tasks include:

  • Diagnostics of microbial toxins that could be used for bioterrorist attacks using techniques based on cell biological, genetical and serological parameters, as well as chromatographic methods and mass spectroscopy
  • Development of SOPs for diagnostics
  • Provision of reference samples, reference bacterial strains and standards, storage of diagnostic material
  • Adaptation of the diagnostic materials to the expected sample material
  • Development of strategies for the detection of novel and modified toxins and agents
  • Research on the pathogenesis of the diseases induced
  • Interlaboratory experiments to assure the quality of diagnostics
  • Contribution to the development of standard therapies
  • Characterisation of adherence/colonisation factors in toxin-producing and tissue-damaging bacteria
Diagnostic range
ToxinDetection method
AbrinELISA, funct. methods, spectroscopy*
Clostridium botulinum toxinsELISA, cultivation, functional methods, spectroscopy*, nucleic acid detection, subtyping
Clostridium tetani toxincultivation, functional method, nucleic acid detection
RicinELISA, functional methods, spectroscopy*, nucleic acid detection
Staphylococcal enterotoxin B from S. aureusELISA, cultivation, spectroscopy*

* carried out at ZBS 6

Please call us before you submit any samples.

Accreditation

Akkreditierung ausgewählter Verfahren nach DAkkS

Logo für Akkreditierung des Labors

Selected methods are
accredited to
DIN EN ISO 15189 and
DIN EN ISO/IEC 17025 

Further information