Unit 15: Gastroenteritis and Hepatitis Pathogens and Enteroviruses
Date: 16/04/2025
- Leader:
- N. N.
- Deputy:
- Dr. Sabine Diedrich
Tasks
Viral gastroenteritides
Consultant Laboratory for Noroviruses
- Molecular-epidemiological analyses on the circulation of noroviruses and other gastroenteritis viruses (pathogen variability, transmission)
- Investigations on the recombination of viral RNA
- Pathogenesis of norovirus infection
- Cooperation within the European "NoroNet" for the surveillance of norovirus circulation in Europe
Consultant Laboratory for Rotaviruses
- Molecular detection of rotaviruses of Group A, B and C
- Molecular-epidemiological investigations on the circulation of rotavirus A (G/P typing)
- Differentiation of wild and vaccine viruses
Poliomyelitis and enteroviruses
National Reference Centre for Poliomyelitis and Enteroviruses (NRC PE) and Regional Reference Laboratory of the WHO/EURO for Poliomyelitis
- Detection of enteroviruses in patients with aseptic meningitis/encephalitis and acute flaccid paralyses
- Molecular epidemiologic analysis of selected picornavirus serotypes
- Intratypical differentiation of poliovirus isolates using molecular methods (PCR, sequencing in different genome regions)
Office of the National Certification Commission for Poliomyelitis Eradication in Germany
- Surveillance of polio-free status of Germany within the context of the WHO programme for the eradication of poliomyelitis (National Enterovirus Surveillance)
- Coordination of the laboratory network for enterovirus diagnostics in Germany (LaNED)
- Monitoring of laboratory containment for polioviruses (§ 50a IfSG)
Viral hepatitis
Laboratory for Hepatitis Virus Infections
- Molecular-epidemiological investigations on the circulation of hepatitis viruses (HEV, HBV and HCV)
- Variability of hepatitis viruses, especially HEV, in connection with persistence and therapy resistance
- Molecular mechanisms of cellular interference mechanisms and pathogenesis of hepatitis viruses (HEV)