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ZBS 3: Biological Toxins
Consultant laboratory for neurotoxin-producing clostridia (botulism, tetanus)
- Head:
- Brigitte Dorner
- Deputy:
- Martin Dorner
Tasks include:
- Diagnostics of microbial toxins that could be used for bioterrorist attacks using techniques based on cell biological, genetical and serological parameters, as well as chromatographic methods and mass spectroscopy
- Development of SOPs for diagnostics
- Provision of reference samples, reference bacterial strains and standards, storage of diagnostic material
- Adaptation of the diagnostic materials to the expected sample material
- Development of strategies for the detection of novel and modified toxins and agents
- Research on the pathogenesis of the diseases induced
- Interlaboratory experiments to assure the quality of diagnostics
- Contribution to the development of standard therapies
- Characterisation of adherence/colonisation factors in toxin-producing and tissue-damaging bacteria
| Toxin | Detection method |
|---|---|
| Abrin | ELISA, funct. methods, spectroscopy* |
| Clostridium botulinum toxins | ELISA, cultivation, functional methods, spectroscopy*, nucleic acid detection, subtyping |
| Clostridium tetani toxin | cultivation, functional method, nucleic acid detection |
| Ricin | ELISA, functional methods, spectroscopy*, nucleic acid detection |
| Staphylococcal enterotoxin B from S. aureus | ELISA, cultivation, spectroscopy* |
* carried out at ZBS 6
Please call us before you submit any samples.
Date: 26.01.2022
