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29.1.2019, Berlin: Using principal stratification to address post-randomization events: A case study

Anfang:
29.01.2019, 17:00 Uhr
Ende:
29.01.2019, 18:30 Uhr
Veranstaltungsort:
Robert Koch-Institut, Nordufer 20, 13353 Berlin, Hörsaal

Referent: Baldur Magnusson (Novartis Pharma AG)

Zusammenfassung: "In a randomized controlled trial, occurrence of post-randomization events associated with treatment and the primary endpoint may complicate the interpretation of the overall treatment effect. In this presentation, we discuss how these events may be accounted for at the estimand and the estimator level in the context of a recent case study. We define a principal stratification estimand derived from the scientific question of interest. Consideration is given to identifying assumptions, model-based derivation of an estimator, handling of covariates and missing data. We also discuss the role of sensitivity analyses."

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Das Robert Koch-Institut ist ein Bundesinstitut im Geschäftsbereich des Bundesministeriums für Gesundheit

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