Navigation und Service


Abstract zur Publikation: Cohort profile: the German ClinSurv HIV project – a multicentre open clinical cohort study supplementing national HIV surveillance

Bätzing-Feigenbaum J, Kollan C, Kuehne A, Matysiak-Klose D, Gunsenheimer-Bartmeyer B, Hamouda O; ClinSurv Study Group (2011): Cohort profile: the German ClinSurv HIV project – a multicentre open clinical cohort study supplementing national HIV surveillance.
HIV Med. 12 (5): 269-278. Epub 2010 Oct 18. DOI: 10.1111/j.1468-1293.2010.00879.x.


New forms of HIV/AIDS therapy require new surveillance instruments to meet shifting public health demands. The Clinical Surveillance of HIV Disease (ClinSurv HIV) project was established in 1999 as a collaboration between major HIV treatment centres in Germany and the Robert Koch Institute (RKI). The project contributes to national HIV surveillance and focuses on the changing epidemiology of HIV/AIDS after the introduction of new therapies in 1995.


ClinSurv HIV is designed as an open multicentre observational cohort study of HIV-infected patients. Anonymized data on diagnoses, treatment and laboratory parameters are collected in a standardized format. Data are currently sampled biannually via 11 centres specializing in HIV diagnosis and care within the legal framework of the German Protection against Infection Act [Infektionsschutzgesetz (IfSG)].


A total of 14 874 patients were enrolled in the study by 30 June 2009. Of these, 10 221 patients (68.7%) were enrolled after 1 January 1999 and 6006 patients (40.4%) were known to have been diagnosed as positive for HIV before 1999. Evaluation indicators, such as the number of newly enrolled patients per half-year period, loss to follow-up, completeness of data per case, availability of data per possible clinical contact, and internal quality control parameters, show a very stable evolution in the cohort, which although open, can be observed. Comparison with the national HIV surveillance data suggests a high degree of representativeness according to major demographic variables.


Bearing in mind the obvious strengths and weaknesses discussed, the German ClinSurv HIV cohort provides a broad range of research opportunities in the field of HIV/AIDS both within Germany and in international collaborative research.







Das Robert Koch-Institut ist ein Bundesinstitut im Geschäftsbereich des Bundesministeriums für Gesundheit

© Robert Koch-Institut

Alle Rechte vorbehalten, soweit nicht ausdrücklich anders vermerkt.