Unit 12: Measles, Mumps, Rubella, and Viruses Affecting Immunocompromised Patients
- Head:
- Annette Mankertz
- Deputy:
- Sebastian Voigt
The unit is engaged in the monitoring of vaccine-preventable virus infections (measles, mumps, rubella, varicella) in Germany and the clarification of molecular and pathogenetic properties of human pathogenic herpes-, polyoma-, paramyxo- and adenoviruses. The task of a National Reference Centre is taken over for measles, mumps and rubella. There is a close integration into the sentinel systems for Germany as well as in the global networks and elimination programmes of WHO.
Tasks
Measles, mumps, rubella
- National Reference Centre for measles, mumps, rubella
- Regional Reference Laboratory of the WHO, Region Europe
- Genetic characterisation of currently circulating measles and mumps viruses
- Investigation on population immunity against measles, mumps and rubella viruses
- Investigations on the efficacy of MMR vaccines, mapping of immunorelevant epitopes
- Analysis of virulence factors of paramyxoviruses
Herpesviruses
- Laboratory-supported monitoring of vaccination against varicella within the framework of national surveillance
- Investigation on the tolerability and efficacy of varicella vaccines
- Identification and clarification of immune-subversive gene functions of the cytomegalovirus
- Small animal model of the cytomegalovirus infection
- Connatal and perinatal cytomegalovirus infections
- Rapid detection of therapy-resistant mutants of the cytomegalovirus
Polyomaviruses, Adenoviruses
- Adoptive immunotherapy for adenovirus-associated complications in children after haematopoietic stem cell transplantation
- Clarification of the epidemiology and pathogenesis of novel polyomaviruses
- Zoonotic potential of polyoma- and adenoviruses
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