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Consultant Laboratory for Poxviruses at the Robert Koch-Institut

Head:
Andreas Nitsche
Deputy:
Livia Schrick

The Consultant Laboratory for Poxviruses employs various diagnostic methods to identify an infection with poxviruses.

In addition to classical virological methods, modern molecular methods are refined in order to enable a rapid and reliable detection and typing of poxviruses. Further detailed information on human poxviruses and on the vaccination against poxviruses, see here (in German).

Besides human poxviruses (Variola/smallpox) other human-pathogenic poxviruses can also be differentiated, e.g. cowpox-, monkeypox- and parapoxviruses as well as animal-pathogenic poxviruses like Ectromelia.

Tasks

Products and services:

When sending diagnostic samples the senders are requested to contact the lab beforehand (+49-30-187542313 or 2763).

  • Consultant Lab for Poxviruses, ZBS 1
    Robert Koch-Institut
    Seestrasse 10
    13353 Berlin
    Germany
  • Information regarding transport of samples (in German)

Date: 06.01.2016

Publications

  • Kurth A, Straube M, Kuczka A, Dunsche AJ, Meyer H, Nitsche A (2009): Cowpox Virus Outbreak in Banded Mongooses (Mungos mungo) and Jaguarundis (Herpailurus yagouaroundi) with a Time-Delayed Infection to Humans.
    PLoS One 4 (9): e6883. Epub 3 Sep. more

  • Schroeder K, Nitsche A (2009): Multicolour, multiplex real-time PCR assay for the detection of human-pathogenic poxviruses. Short Communication.
    Mol. Cell. Probes: Epub Oct 29. doi:10.1016/j.mcp.2009.10.008. more

  • Strenger V, Müller M, Richter S, Revilla-Fernandez S, Nitsche A, Klee SR, Ellerbrok H, Zenz W (2009): A 17-year-old girl with a black eschar. Cowpox virus infection.
    Clin. Infect. Dis. 48 (1): 91-92, 133-134.

  • Kuczka A, Nitsche A, Höveler R, Becker C, Kurth A (2009): Ein Bericht über durch Heimtierratten auf Menschen übertragene Kuhpockenvirusinfektion.
    Dt. Tierärztebl. 3: 316-319. more

  • Becker C, Kurth A, Hessler F, Kramp H, Gokel M, Hoffmann R, Kuczka A, Nitsche A (2009): Cowpox Virus Infection in Pet Rat Owners - Not Always Immediately Recognized.
    Dtsch. Arztebl. Int. 106 (19): 329-334. more

  • Witkowski PT, Bourquain D, Hohn O, Schade R, Nitsche A (2008): Gene Gun-supported DNA Immunisation of Chicken for Straightforward Production of Poxvirus-specific IgY Antibodies.
    J. Immunol. Methods: Epub 17 Dec. more

  • Kurth A, Achenbach J, Miller L, Mackay IM, Pauli G, Nitsche A (2008): Orthopoxvirus Detection in Environmental Specimens during Suspected Bioterror Attacks: Inhibitory Influences of Common Household Products.
    Appl. Environ. Microbiol. 74 (1): 32-37. more

  • Kurth A, Wibbelt G, Gerber H-P, Petschaelis A, Pauli G, Nitsche A (2008): Rat-to-elephant-to-human transmission of cowpox virus [letter].
    Emerg. Infect. Dis. 14 (4): 670-671.

  • Bonnekoh B, Falk K, Reckling KF, Kenklies S, Nitsche A, Ghebremedhin B, Pokrywka A, Franke I, Thriene B, König W, Pauli G, Gollnick H (2008): Cowpox infection transmitted from a domestic cat.
    J. Dtsch. Dermatol. Ges. 6 (3): 210-213. more

  • Schroeder K, Nitsche A (2009): Multicolour, multiplex real-time PCR assay for the detection of human-pathogenic poxviruses. Short Communication.
    Mol. Cell. Probes: Epub Oct 29. doi:10.1016/j.mcp.2009.10.008. more

  • Kurth A, Straube M, Kuczka A, Dunsche AJ, Meyer H, Nitsche A (2009): Cowpox Virus Outbreak in Banded Mongooses (Mungos mungo) and Jaguarundis (Herpailurus yagouaroundi) with a Time-Delayed Infection to Humans.
    PLoS One 4 (9): e6883. Epub 3 Sep. more

  • Strenger V, Müller M, Richter S, Revilla-Fernandez S, Nitsche A, Klee SR, Ellerbrok H, Zenz W (2009): A 17-year-old girl with a black eschar. Cowpox virus infection.
    Clin. Infect. Dis. 48 (1): 91-92, 133-134.

  • Kuczka A, Nitsche A, Höveler R, Becker C, Kurth A (2009): Ein Bericht über durch Heimtierratten auf Menschen übertragene Kuhpockenvirusinfektion.
    Dt. Tierärztebl. 3: 316-319. more

  • Becker C, Kurth A, Hessler F, Kramp H, Gokel M, Hoffmann R, Kuczka A, Nitsche A (2009): Cowpox Virus Infection in Pet Rat Owners - Not Always Immediately Recognized.
    Dtsch. Arztebl. Int. 106 (19): 329-334. more

  • Witkowski PT, Bourquain D, Hohn O, Schade R, Nitsche A (2008): Gene Gun-supported DNA Immunisation of Chicken for Straightforward Production of Poxvirus-specific IgY Antibodies.
    J. Immunol. Methods: Epub 17 Dec. more

  • Kurth A, Achenbach J, Miller L, Mackay IM, Pauli G, Nitsche A (2008): Orthopoxvirus Detection in Environmental Specimens during Suspected Bioterror Attacks: Inhibitory Influences of Common Household Products.
    Appl. Environ. Microbiol. 74 (1): 32-37. more

  • Kurth A, Wibbelt G, Gerber H-P, Petschaelis A, Pauli G, Nitsche A (2008): Rat-to-elephant-to-human transmission of cowpox virus [letter].
    Emerg. Infect. Dis. 14 (4): 670-671.

  • Bonnekoh B, Falk K, Reckling KF, Kenklies S, Nitsche A, Ghebremedhin B, Pokrywka A, Franke I, Thriene B, König W, Pauli G, Gollnick H (2008): Cowpox infection transmitted from a domestic cat.
    J. Dtsch. Dermatol. Ges. 6 (3): 210-213. more

  • Nitsche A, Gelderblom HR, Eisendle K, Romani N, Pauli G (2007): Pitfalls in diagnosing human poxvirus infections.
    J. Clin. Virol. 38 (2): 165-168.

  • Nitsche A, Kurth A, Pauli G (2007): Viremia in human Cowpox virus infection.
    J. Clin. Virol. 40 (2): 160-162. more

  • Nitsche A, Pauli G (2007): Sporadic human cases of cowpox in Germany.
    Euro Surveillance 12 (4): E070419.3.

  • Kurth A, Nitsche A (2007): Fast and reliable diagnostic methods for the detection of human poxvirus infections.
    Future Virology 2 (5): 467-479. more

  • Nitsche A, Büttner M, Wilhelm S, Pauli G, Meyer H (2006): Real-time PCR detection of Parapoxvirus DNA.
    Clin. Chem. 52 (2): 316-319. more

  • Nitsche A, Stern D, Ellerbrok H, Pauli G (2006): Detection of Infectious Poxvirus Particles.
    Emerg. Infect. Dis. 12 (7): 1139-1141. more

  • Niedrig M, Meyer H, Panning M, Drosten C (2006): Follow-Up on Diagnostic Proficiency of Laboratories Equipped To Perform Orthopoxvirus Detection and Quantification by PCR: the Second International External Quality Assurance Study.
    J. Clin. Microbiol. 44 (4): 1283-1287. more

  • Nitsche A, Steger B, Ellerbrok H, Pauli G (2005): Detection of vaccinia virus DNA on the LightCycler by fluorescence melting curve analysis.
    J. Virol. Methods 126 (1-2): 187-195. more

  • Olson VA, Laue T, Laker MT, Babkin IV, Drosten C, Shchelkunov SN, Niedrig M, Damon IK, Meyer H (2004): Real-time PCR system for detection of orthopoxviruses and simultaneous identification of smallpox virus.
    J. Clin. Microbiol. 42 (5): 1940-1946. more

  • Nitsche A, Ellerbrok H, Pauli G (2004): Detection of Orthopoxvirus DNA by Real-Time PCR and Identification of Variola Virus DNA by Melting Analysis.
    J. Clin. Microbiol. 42 (3): 1207-1213. more